Th5487 ogg1
Web19 Nov 2024 · Dubbed TH5487, the new molecule blocks the action of a key inflammation-triggering enzyme, 8-oxoguanine DNA glycosylase 1 (OGG1). This enzyme is known to … Web28 Feb 2024 · In this study, a novel small molecule OGG1 inhibitor, TH5487, decreased myofibroblast transition and associated pro-fibrotic markers in fibroblast cells. In …
Th5487 ogg1
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WebTH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and … Web18 Nov 2024 · Additionally, the interaction of OGG1 with viral MGF360-14-L protein could disturb IFN-β production to further affect ASFV replication. These results suggest that OGG1 plays the crucial role in successful viral infection and OGG1 inhibitors SU0268 or TH5487 could be used as antiviral agents for ASFV infection.
Web1 Aug 2024 · These discoveries suggest OGG1 is required for TH5487 to exert its anti-fibrotic effect in the murine BLM model. Currently, all studies regarding TH5487 are based … http://probechem.com/products_TH5487.aspx
WebCompare TH5487 (TH-5487) from Biorbyt on Biocompare.com. Specifications/Features Application Notes: TH5487 (TH-5487, TH 5487) is a potent, selective, active-site inhibitor … WebA small-molecule drug that acts as a potent and selective active-site inhibitor that stops OGG1 from recognizing its DNA substrate and hampers Ogg1 binding to and repair of 8-oxoG is developed, which is well tolerated by mice and presents a proof of concept that targeting oxidative DNA repair can alleviate inflammatory conditions in vivo. DNA binding …
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Web14 Jan 2024 · TH5487. CAS No. : 2304947-71-3. Biological Activity：TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC 50 of 342 nM. TH5487 stops … trip ae reviewWeb16 Nov 2024 · By exploiting this newly recognized role of OGG1 and identifying the potent TH5487 inhibitor, Visnes et al. have developed a new approach to combating the ravages … trip agenda templateWeb3 Feb 2024 · FIGURE 1.The addition of OGG1 competitive inhibitors TH5487 and SU0268 to the medium results in higher staining with fluorescent dyes. (A) U2OS cells were stained … trip ae englishWeb26 Oct 2024 · This study validates TH5487 as a potent OGG1 inhibitor that prevents the repair of 8-oxoG and alters OGG1–chromatin dynamics and OGG1′s recruitment kinetics. 8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision … trip ahlenWeb2 Dec 2024 · The indicated concentrations TH5487 were spotted in 6-well plates using a Tecan D300e digital dispenser. 200–500 cells/well H460, ACHN, Ogg1−/− mouse … trip affiliateWeb1 Jun 2024 · Cells of the aerobic metabolic organism are inevitably subjected to the damage from reactive oxygen species (ROS). ROS cause multiple forms of DNA damage, among which the oxidation product of guanine G 8-hydroxyguanine (8-oxoG) is the most frequent DNA oxidative damage, recognized by the specific glycosidase OGG1 that initiates the … trip aided and complex phase steelsWebIt has been reported that oxidative stress and chronic inflammation may be involved in the pathogenesis of polycystic ovary syndrome (PCOS). 8-oxoguanine DNA glycosylase (OGG1) is the main glycosylase that catalyzes the excision of DNA oxidation products. In this study, we investigated the role and potential mechanisms of OGG1 in the development of PCOS. … trip ahoy