Other name for argatroban
WebApr 3, 2024 · Argatroban is a small molecule which directly inhibits thrombin (factor IIa)(figure above). Argatroban is cleared by the liver with a ~45-minute half-life. In patients with normal hepatic function, coagulation will normalize about 2-4 hours after stopping the infusion. The half-life may extend to ~3 hours in patients with hepatic dysfunction. WebBackground: In recent years, several selectively acting anticoagulants, including the direct thrombin inhibitors (DTI; argatroban, dabigatran) and the factor Xa inhibitors (rivaroxaban, apixaban, fondaparinux), have been developed. With their clinical application increasing, it is of interest to evaluate their interference with classical haemostaseological point-of-care …
Other name for argatroban
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WebMar 2, 2024 · Uses for Argatroban Heparin-induced Thrombocytopenia (HIT) Prevention and treatment of thrombosis in patients with HIT. In patients with acute HIT or HIT and thrombosis syndrome (HITTS), all forms of heparin (e.g., unfractionated heparin, low molecular weight heparin [LMWH]) should be discontinued and a nonheparin … WebMar 14, 2024 · Argatroban usually does not affect the functioning of the liver. But, long-term use of Argatroban may increase the chances of mild liver injury in patients with elevated liver enzymes. However, the overall chances of developing any such problems are lower than other anticoagulants.
WebMar 27, 2024 · Buy Argatroban Related Compound A ((2R,4R)-1-[N8 ... Product Name Price range Estimated delivery; Technical inquiry about: 45-1042419 Argatroban ... It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages. Given name * Surname * Email * Phone. Please make sure to include the country ... WebCAS No.: 74874-10-5: Other Names: Argatroban Intermediates: MF: C20H25ClN2O5.CH4O3SH2O: Place of Origin: Shaanxi, China: Type: Auxiliaries and Other Medicinal ...
WebOther formulations of argatroban are described in U.S. Pat. Nos. 5,679,690 and 6,087,375, European Patent Applications 0,565,897 A1 and 0,621,036 A1 and WO 2005/009361 A2. BRIEF SUMMARY OF THE INVENTION. [0004] The present invention provides an aqueous, stable, sterile pharmaceutical composition of a thrombin inhibitor suitable for parenteral ... WebArgatroban is highly selective for thrombin with an inhibitory constant (Ki) of 0.04 µM. At therapeutic concentrations, Argatroban has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein). Argatroban is capable of inhibiting the action of both free and clot-associated thrombin.
WebRx Item-Argatroban 50MG 10X50 ML Vial by Chiesi Pharma USA, Item No. RX135020, 135020 ... GENERIC Other Names: Argatroban Inj, Argatroban, Argatroban ... Information and statements regarding dietary supplements and many other health conditions on this site have not been evaluated by the Food and Drug Administration and are not intended ...
WebArgatroban is a potent agent and despite other parenteral DTIs binds reversibly to the active site of both free and clot-bound thrombin (Haqqani et al., 2013). The intravenous administration of both argatroban and bivalirudin has a rapid onset, and lack of interaction with heparin-PF4 antibodies (Fritsma, 2024). pall mcWebArgatroban is capable of inhibiting the action of both free and clot-associated thrombin. Structure. Argatroban is a synthetic direct thrombin inhibitor and the chemical name is 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-(1,2,3,4-tetrahydro-3-methyl-8- quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid, monohydrate. エヴァ 装備一覧WebArgatroban is a synthetic small molecule derived from l-arginine with specific antithrombotic activity. Argatroban is a direct thrombin inhibitor that binds avidly and reversibly to the catalytic site of thrombin and that does not require other cofactors to exert its antithrombotic action. エヴァ 見る順番 知恵袋エヴァ 街 赤いWebProduct Name: Argatroban: Synonyms: ... Other potential uses include progressing ischemic stroke and disseminated intravascular coagulation. Description: Argatroban is a reversible inhibitor of thrombin (IC 50 s = 0.01 and 0.09 μM for … エヴァ 装備WebArgatroban distributes mainly in the extra-cellular fluid. The volume of distribution (Vdβ) was 391 ± 155 ml/kg (mean ± SD). Argatroban is 54% bound in human serum proteins, with binding to albumin and α 1-acid glycoprotein being 20% and 34% respectively. Biotransformation. The metabolism of argatroban has not yet been fully characterized. エヴァ 袋WebArgatroban (Ingredient) Chemical formula: C23H36N6O5S Drugbank ID: DB00278 ATC code: B01AE03. The information below refers to products available in the United States that contain argatroban. Products containing argatroban argatroban systemic. Brand name: Acova Drug class: thrombin inhibitors. Argatroban systemic is used in the treatment of: pallme oschatz