WebMIF serum levels were similar between SSc patients and CS: dcSSc = 3.82 ng/ml, lcSSc = 3.57 ng/ml, and CS = 3.28 ng/ml. In skin biopsies of SSc, MIF and CD74 were enhanced in keratinocytes, while they showed decreased expression in endothelial cells. On the other hand, the staining of CD74 was high in fibroblasts of dcSSc patients. Web28 jan. 2024 · Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine with anti-fibrotic properties in toxic liver injury models and anti-steatotic functions in non-alcoholic fatty liver disease (NAFLD) attributed to the CD74/AMPK signaling pathway.
Frontiers Role of MIF Cytokine/CD74 Receptor Pathway …
Web4 apr. 2024 · Soluble CD74 Redirects the Profibrotic MIF/CXCR4 Signal into an Antifibrotic MIF/CD74 Signal. As mentioned before, the dual role of MIF in MI and cardiac … Web23 aug. 2024 · Urothelial MIF receptors CD74 and CXCR4 mediate bladder pain through release of urothelial HMGB1. This mechanism may set up persistent pain loops in the bladder and warrants further investigation. Urothelial CD74 and CXCR4 may provide novel targets for interrupting bladder pain. pt to sofia
MIF, CD74 and other partners in kidney disease: tales of a ... - P…
Web4 mrt. 2024 · CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF), and its mRNA is known to be expressed in HSCs. Here, we demonstrate that mice lacking CD74... WebMethods: Single cell data of 4 normal samples, 3 CRPC samples and 3 CRPC-NE samples were obtained from GEO database, and CellChatDB was used for potential intercellular communication, Secondly, using the “limma” package (v3.52.0), we obtained the differential expressed genes between CRPC and CRPC-NE both in single-cell RNA seq and bulk … Web4 feb. 2024 · CD74 is a type-II transmembrane glycoprotein that has been shown to have two biological functions. First, CD74 functions as a chaperone and a transport cofactor … hot comb in a jar