Long-range chromosomal interactions
Web3 de jul. de 2013 · To investigate whether long-range interactions at the Oct4 locus are specific to PSCs, we compared colocalization frequency in iPSCs, ESCs, pre-iPSCs (or … WebLong-range chromosomal interactions is important for regulation of gene transcription and genome maintenance. 6 The role of YY1 in chromosomal interactions has been shown in B cell development, in which the IgH (encoding immunoglobulin heavy [IgH] chain) locus undergoes contraction for rearrangement by forming loops.
Long-range chromosomal interactions
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WebAn overview of recently discovered long-range chromosomal interactions is presented, and a network approach is proposed to unravel gene-element relationships. Gene … Web13 de fev. de 2024 · Wei Z, Gao F, Kim S, Yang H, Lyu J, An W, et al. Klf4 organizes long-range chromosomal interactions with the Oct4 locus in reprogramming and …
Web1 de jun. de 2003 · Detection of long-range chromosomal interactions. (a) Chromosome conformation capture (3C) analysis uses formaldehyde to cross-link protein-mediated interactions between distant loci (black line indicates DNA, gray circles indicate protein). After digestion and ligation, interactions are detected by PCR using primers that … Web17 de jul. de 2014 · Moreover, seeing is believing—the live images provided by Lucas et al. (2014) are convincing and elegant and leave little doubt that, once the “stage is set,” long-range chromosomal interactions occur rapidly and efficiently, even over Mb distances. The key to speed is spatial confinement.
WebInterestingly, oncogenic SNP rs6983267 within the c-MYC enhancer region increase CCAT 1 expression by long-range interaction with CCAT 1 promoter region . In addition, studies suggest that overexpression of CAMP responsive element binding protein 1 (CREB1), a phosphorylation-dependent transcription factor cause upregulation of CCAT1 ( 75 ). Web23 de mai. de 2011 · Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V H genes to be brought in proximity with D H-J H segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF) has been demonstrated to be …
WebA general mechanism by which a gene can be held in a poised state until the appropriate stage for expression, coordinating the level and timing of gene expression during terminal differentiation is pointed to. To understand how mammalian genes are regulated from their natural chromosomal environment, we have analysed the molecular events occurring …
Web2 de mai. de 2016 · Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression PLoS Genet. 2016 May 2;12(5):e1005992. doi: … california megaflood studyWebLong-range interactions are reproducible and increase across adipogenesis. To link regulatory elements involved in adipogenesis to their target genes, we performed promoter Capture Hi-C (pCHi-C) in human primary preadipocytes (PAd), differentiating preadipocytes (day 1, Diff), and fully in vitro differentiated adipocytes (day 14, Adip) (Supplementary … california mega earthquakeWeb7 de mar. de 2016 · 3 Three-Dimensional Chromosomal Organization and Long-Range Interaction The organization of a eukaryotic genome in the three-dimensional (3D) … california megaflood hoaxWeb9 de jun. de 2024 · With the advancement of 3C-based techniques, it is now possible to not only map long-range “cis” and “trans” chromosomal interactions at specific genomic regions, but also provide ... coastal bend blood bankWeb2 de jun. de 2009 · The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising … coastal bend cbcWeb2 de ago. de 2013 · Studying Long-range Chromosomal Interactions with FISH- and 3C-based Methods. Nuclear organization was initially explored using imaging analysis such as FISH-based methods ().Multicolor FISH provided direct evidence for chromosome territories ().FISH was also used to correlate transcriptional activity with position of genes within a … california megaflood predictionWeb13 de mai. de 2024 · In addition, long-range cis-interactions between Polycomb-bound regions, which are among the strongest chromosomal interactions in mouse ESCs, … california mega millions lottery ticket