Intrastrand adducts
WebMar 1, 1997 · Fraction of interstrand crosslinks formed at a G-G-C site in double- and single-stranded DNA a. 22, 23), the equilibrium conformations of both mechlorethamine and … WebMay 25, 2016 · It is thought that DNA intrastrand adducts at GG sequences are the significant sites of cisplatin’s biological effectiveness and anti-tumour activity [11, 12]. …
Intrastrand adducts
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WebIn the SiHa cells, MDC1-AS of MTCL could form RNA-RNA dimer with MDC1 and thereby protect MDC1 from degradation by RNase. This process increased the stability and …
WebThe solution structure was determined using the SPEDREF protocol, which includes an iterative NOE-restrained refinement procedure. Calculated and recorded NOE spectra … WebApr 1, 1990 · Nuclear Magnetic Resonance Solution Structures of Inter- and Intrastrand Adducts of DNA Cross-Linker SJG-136. Biochemistry 2011, 50 (21) , ... Repair of helix-stabilizing anthramycin-N2 guanine DNA adducts by UVRA and UVRB proteins. Journal of Molecular Biology 1991, 220 (4) , ...
WebApr 10, 2024 · The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand … WebApr 19, 2016 · It reacts with purine residues to form intrastrand and interstrand crosslinks. The intrastrand crosslinks are formed at sequences GpG and ApG with a preference for …
WebII) 1,2-d(GpA) intrastrand cisplatin crosslinks, which are the second-most heavily formed adducts. III) 1,3-d(GpXpG) intrastrand cisplatin cross-links, which are only formed …
WebThe solution structure was determined using the SPEDREF protocol, which includes an iterative NOE-restrained refinement procedure. Calculated and recorded NOE spectra were found to be in good agreement (NMR R factor 22%). The studied duplex is more distorted from B-DNA than previously determined structures of the 1,2-d(GG) intrastrand adducts. champ home inspections gaWebThey are stable within single-stranded oligonucleotides. The pairing of the platinated single-stranded oligonucleotides with their complementary strands triggers the rearrangement … happy trails promotional codeWebPlatinum chemotherapeutic agents have been widely used in the treatment of cancer. Cisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent forms several DNA adducts, a highly sensitive and specific quantitative assay is needed … happy trails lodge south dakotaWebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.. Common side effects include bone marrow suppression, hearing … happy trails preschool yumaWebMay 26, 2009 · Because trans-diamminedichloroplatinum(ii) is incapable of forming 1,2-intrastrand cross-links on DNA, 32, 33 and because this complex has insignificant antitumor activity in cells, 34 intrastrand adducts are more likely to be responsible for the cytotoxicity of cisplatin in cancer cells. happy trails rabbitryWebMar 19, 2014 · Firstly, they are able to alter the tertiary structure of DNA by forming intrastrand adducts and interstrand crosslinks. 62 Moreover, it has been documented … happy trails plush rocking horse - brownWebSep 1, 1999 · Intrastrand DNA adducts formed by cisplatin and oxaliplatin were modeled with molecular mechanics minimization and restrained molecular dynamics simulations in … champ hood