Cyanotoxin genotoxicity: a review
WebDec 1, 2010 · In this review, possible genotoxic effects of well-known cyanotoxins (Cylindrospermopsin, Microcystin-LR, Nodularin, Anatoxin-a and Homoanatoxin-a) were … WebJun 1, 2024 · It is generally known that CYN is a pro-genotoxic and has to be metabolically activated by CYP450 enzymes to induce genotoxic effects, which was confirmed in several in vitro [29,31,32,34, 36,...
Cyanotoxin genotoxicity: a review
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WebThe properties of the most frequently detected cyanotoxins (namely, microcystins, nodularins, cylindrospermopsin and neurotoxins) are here critically reviewed, describing for each toxin the available information on producing organisms, biosynthesis/genetic … WebJan 1, 2011 · In this review we discuss genotoxic and potential carcinogenic properties of freshwater cyanotoxins, particularly microcystin-LR (MCLR), nodularin (NOD) and …
WebNov 6, 2024 · CYN exerts multiple toxicities which may include cytotoxicity, hepatotoxicity, genotoxicity, neurotoxicity, and immunotoxicity [7,75,87]. ... Wood, R. Acute animal and … WebNov 1, 2024 · This review comprehensively describes the major toxicological impacts (such as hepatotoxicity, neurotoxicity, immune toxicity, reproductive toxicity and …
WebThe results showed that after 72 h exposure genotoxic activity of CYN/MCLR mixture was comparable to the one of pure CYN, while MCLR had no effect on the viability of cells and had no influence on cell division. Simultaneous occurrence of cylindrospermopsin (CYN) and microcystin-LR (MCLR) has been reported in the aquatic environment and thus human … WebJul 16, 2024 · A study showed that CYN is linked to a variable effect in HepG2 cell line. Cyanotoxin diminishes lipid peroxidation in cells that have not been previously …
WebJan 1, 2011 · This review gives an overview of cyanotoxins' analysis and levels in freshwater environments with particular emphasis on seasonal variations in Europe. Recent analytical approaches are discussed and the seasonal patterns for three major European climate zones (Mediterranean, continental, and Atlantic) were distinguished.
WebOct 1, 2024 · Toxin-producing cyanobacteria in aquatic, terrestrial, and aerial environments can occur alongside a wide range of additional health hazards including biological agents and synthetic materials. Cases of intoxications involving cyanobacteria and cyanotoxins, with exposure to additional hazards, are discussed. Examples of the co-occurrence of … charlie\u0027s steak ribs and ale branson moWebThe toxicity of 5-chlorouracil (as measured by DNA strand breakage) was significantly influenced by time from dosing and there was no significant difference in MML between mice dosed with 5- chloro-6-hydroxymethyluracil and the controls. Cylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other … charlie\\u0027s storeWebFeb 4, 2024 · Neurological damage: The cyanotoxins that affect the nervous system cause neurological symptoms such as tingling, burning, and numbness of the extremities, drowsiness, incoherent speech, excessive salivation, and seizures. They can also lead to respiratory paralysis, which is often fatal. charlie\u0027s steakhouse tampa menuWeb9.2.10 Mutagenicity and genotoxicity. 9.2.10.1 Microcystins; 9.2.10.2 Cylindrospermopsin ... This guideline technical document reviews and assesses the identified health risks associated with cyanobacterial toxins in drinking water. ... over both distance and time (Hotto et al., 2008; Briand et al., 2009). The mechanisms affecting cyanotoxin ... charlie\u0027s store aberystwyth retail parkWebGenotoxic activity of CYN, manifested as oxidative DNA damage and elevated number of micronuclei, was also detected in exposed cells. The obtained results indicate that CYN … charlie\u0027s steakhouse tampa closingWebAug 23, 2024 · A recent review (Svirčev et al. 2024) identified 1118 observations of cyanotoxins in 869 freshwater ecosystems in 66 countries throughout the world. Among the listed cyanotoxin occurrences were 183 verified or strongly suspected associated, and in some cases causative, cyanotoxin poisonings involving humans and/or animals. charlie\u0027s store newtownWebIn this review, possible genotoxic effects of well-known cyanotoxins (Cylindrospermopsin, Microcystin-LR, Nodularin, Anatoxin-a and Homoanatoxin-a) … charlie\u0027s steak ribs and ale