2024 Cleaved cdcp1 sequence

Cleaved cdcp1 sequence

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August undefined, 2024

WebCDCP1 (CUB-domain containing protein 1), also known as Trask or CD318, is a type I transmembrane receptor whose specific role remains unclear. Human CDCP1 is synthesized with a large extracellular domain (ECD) … WebApr 13, 2015 · An in silico analysis of the primary sequence of CDCP1 revealed that the tyrosine residues Y734 and Y743 were both located in an YXXI/L consensus sequence ... It was recently proposed that the cleaved CDCP1 would mainly occur through plasmin in vivo and would have a pro-survival function during metastatic colonization . In our hands, the …

CDCP1 - Wikipedia

WebJan 9, 2014 · ABrogation in vivo of CDCP1 cleavage either by unique cleavage-blocking monoclonal antibody 10-D7 or by inhibition of proteolytic activity of plasmin-like serine proteases with aprotinin prevented β1 integrin/CDCP1 complexing and downstream FAK/Akt signaling concomitant with significant reduction of stromal invasion and spontaneous … CDCP1/Trask is not important for the development of the mouse. Adult mice lacking CDCP1 do not exhibit gross morphologic, reproductive or behavioral abnormalities compared with wild-type mice, and histologic examination of multiple organ systems has shown no significant pathology and no observed histologic differences. CDCP1 is a ligand for CD6, a receptor molecule expressed on certain T-cells and may play a role in their migration and chemotaxis. As such CD… canada post sherwood park alberta

CDCP1 CUB domain containing protein 1 [ (human)] - National Cente…

WebWhile CDCP1 cleavage signaling is crucial for tumor cell survival during late stages of metastasis, namely tissue colonization at the secondary sites, cleaved CDCP1 signals for enhanced motility ... WebFeb 15, 2024 · CDCP1 is highly overexpressed in RAS-driven cancers, and its ectodomain is cleaved by extracellular proteases. Biochemical, biophysical, and structural … WebJun 15, 2024 · Here, we characterized the precise proteolytic isoforms of CUB domain containing protein 1 (CDCP1), a protein overexpressed and specifically cleaved in RAS … fisher and welch dallas

Proteolytic cleavage of CDCP1 contributes to enhanced tumor cell ...

Targeting a proteolytic neo-epitope of CUB-domain containing ... - bioRxiv

WebCDCP1 is a transmembrane protein that is involved in a variety of important biological processes and upregulated in a variety of human solid malignancies; however, its spatial distribution and... WebCDCP1 Antibody detects endogenous levels of total CDCP1 protein. The 140kDa band is full length, glycosylated CDCP1, the 70kDa band is a cleavage product of CDCP1. Species Reactivity: Human Source / Purification fisher and wilsey st petersburgWebFeb 15, 2024 · The cleaved-specific CDCP1 Abs described here demonstrate that specifically targeting c-CDCP1 is effective and has a more favorable safety profile … fisher and wolfe

"WebApr 13, 2024 · IntroductionLocal therapeutic hypothermia (32°C) has been linked experimentally to an otoprotective effect in the electrode insertion trauma. The pathomechanism of the electrode insertion trauma is connected to the activation of apoptosis and necrosis pathways, pro-inflammatory and fibrotic mechanisms. In a whole … " - Cleaved cdcp1 sequence

Cleaved cdcp1 sequence

JCI - Targeting a proteolytic neoepitope on CUB domain …

WebAug 8, 2024 · Therefore, CDCP1 may form a homophilic complex at the plasma membrane through its ECD. CUB1, the domain located furthest from the transmembrane domain, is cleaved and released, and has been detected in the urine of patients with cancer (18,19). CDCP1 cleavage in the ECD induces cell migration in triple-negative breast cancer cells … WebAug 5, 2016 · CDCP1 is a single-pass transmembrane protein with three extracellular CUB domains and a short intracellular tail. Tyrosine phosphorylation of the intracellular …

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WebNX_Q9H5V8 - CDCP1 - CUB domain-containing protein 1 - Sequence. May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. WebFeb 15, 2024 · Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) could enable more effective and safer treatments for solid tumors. CDCP1 is highly overexpressed in RAS-driven cancers, and its ectodomain is cleaved by extracellular proteases.

WebJun 15, 2024 · Here, we characterized the precise proteolytic isoforms of CUB domain containing protein 1 (CDCP1), a protein overexpressed and specifically cleaved in RAS-driven cancers. We validated that the N-terminal and C-terminal fragments of CDCP1 remain associated after proteolysis in vitro and on the surface of pancreatic cancer cells. WebApr 15, 2024 · Using a CDCP1-biased probe, we identify urokinase (uPA) as the master regulator of CDCP1 proteolysis, which acts both by directly cleaving CDCP1 and by activating CDCP1-cleaving plasmin.

WebJan 1, 2014 · CDCP1 was immunoprecipitated with mAb 41–2 from primary CAM tumors treated with control IgG (lane 1), mAb 10-D7 (lane 2) or aprotinin (lane 3) as described in … WebFeb 15, 2024 · Here, the authors generated an antibody that specifically targeted cleaved CDCP1 (c-CDCP1) and developed a drug conjugate, a vector for radioactive ions, …

WebDec 19, 2011 · In contrast to the cleaved CDCP1-WT in control embryos, no cleavage of CDCP1, and little or no tyrosine phosphorylation of the 135-kDa CDCP1 were detected …

WebDec 3, 2012 · This CDCP1 cleavage-induced signaling cascade constitutes a unique mechanism, independent of extracellular matrix remodeling, whereby a proteolytically … fisher and whyte candlesWeb1 day ago · However, in Alzheimer’s and other neurodegenerative diseases, P35 is cleaved into a smaller protein called P25, which can also bind to CDK5 but has a longer half-life than P35. ... They designed their peptide with a sequence identical to that of a segment of CDK5 known as the T loop, which is a structure critical to the binding of CDK5 to P25 canada post sherwood park hoursWebTargeting CDCP1 impairs PDAC cell functions and PDAC tumor growth independently of CDCP1 cleavage status. A CDCP1-targeting antibody is highly effective at delivering imaging radionuclides and cytotoxins to PDAC cells allowing specific detection of tumors by PET/CT imaging and superior anti-tumor effects compared to gemcitabine in in vivo models. fisher and weiser 78624WebMar 29, 2024 · The CDCP1 is cleaved by serine proteases at adjacent sites, arginine 368 (R368) and lysine 369 (K369), which induces cell migration in vitro and metastasis in vivo. CDCP1 was the most significant (FDR adjusted p-value 0.006). Correlation with CDCP1 … MT1-MMP is accumulated at invadopodia by targeted delivery via membrane … Kinase activity was evaluated using phosphorylation site-specific antibodies … CDCP1 is phosphorylated by Src family kinases in its full-length and cleaved … Background: Galectins are beta-galactose specific binding proteins. In human … The CUB domain-containing protein-1 (CDCP1) is a transmembrane molecule … fisher and weismanWebDec 31, 2012 · In summary, sequences of CDCP1 essential for cellular transformation include the most amino-terminal Cub domain and the phosphorylated tyrosine residues. However, the very amino- and … fisher and woods fresh produceWebJan 13, 2024 · The results presented here indicate that TA blocks cleavage of the Plasmin substrate CDCP1. Some reports indicate that the cleaved form of CDCP1 exhibits enhanced oncogenic functions and a different spectrum of protein-protein interactions than the full-length protein (Casar et al., 2014; Law et al., 2016; Wright et al., 2016). … canada post sherwood park phone numberWebJul 24, 2024 · Importantly, CDCP1 appears to be mostly full-length in PME and MCF10A and cleaved in five of five breast cancer cell lines that express CDCP1. Although … canada post ship and click